Hongtai Chen, Liming Fan, Hongxiao Lv, Xiutang Zhang.ACS Applied Materials & Interfaces 2021, 13 Enzyme-Responsive Biopolymeric Nanogel Fibers by Extrusion: Engineering of High-Surface-Area Hydrogels and Application in Bacterial Enzyme Detection. Alhusaini, Kawaljit Kaur, Mohammad Raoufi, Holger Schönherr. Industrial & Engineering Chemistry Research 2021, 60 Functionalization of Nylon-6,6 with Polyetheramine Improves Wettability and Antibacterial Properties. Filippo Rossi, Mauro Zaltieri, Alessandro Sacchetti, Maurizio Masi.Polymeric Delivery of Therapeutic Nucleic Acids. ACS Applied Materials & Interfaces 2022, 14 Herceptin-Conjugated DOX-Fe3O4/P(NIPAM-AA-MAPEG) Nanogel System for HER2-Targeted Breast Cancer Treatment and Magnetic Resonance Imaging. Xiaojuan Zhang, Pengfei Wei, Zhao Wang, Yuan Zhao, Wenke Xiao, Yong Bian, Dong Liang, Qing Lin, Wenli Song, Wei Jiang, Huan Wang.Hyaluronic Acid–Polyethyleneimine Nanogels for Controlled Drug Delivery in Cancer Treatment. Giannitelli, Filippo Pinelli, Xiaoyu Han, Danila Del Rio, Franca Abbruzzese, Francesco Basoli, Laura Rosanò, Stefano Scialla, Marcella Trombetta, Giuseppe Gigli, Zhenyu J. Emanuele Limiti, Pamela Mozetic, Sara M.Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N-isopropylacrylamide)s in Water. Nobuyuki Morimoto, Florence Segui, Xing-Ping Qiu, Kazunari Akiyoshi, Françoise M.This article is cited by 43 publications. A brief mention is also accorded to the functionalization approach to produce detectable nanogels in vitro and in vivo, ensuring their traceability over time. This review discusses the key role of nanogel functionalization to design promising nanonetworks for drug and gene delivery, highlighting how modification of the polymer meets the challenges of biomolecule transport, and summarizes the most recent results recorded in these fields. Moreover, the functionalization techniques offer the opportunity to improve load protection until the desired area is reached and synthesize nanosystems that are sensitive to biological stimuli. The orthogonal functionalization of polymer chains with different chemical groups allows grafting of specific moieties and conjugating biomolecules, such as peptides, proteins, and growth factors, to give rise to nanogels that are not only more attractive but also more efficient in drug and gene delivery, with the ability to reach specific sites and trigger selective therapies. However, only the combination of different starting polymers is not enough for the development of selective and targeted nanocarriers. In particular, researchers have identified nanogels as promising tools in response to the critical issues of intracellular delivery: because of their peculiar properties, including swelling behavior, nanogels are able to cross the cellular membrane (clathrin-mediated endocytosis, caveolin-mediated endocytosis, phagocytosis, and macropinocytosis) and release their cargo in the cytosol, avoiding the activation of immune responses. The design of nanostructures carrying therapeutic molecules represents the new frontier in the biological and medical fields.
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